Abstract:

A study was conducted to determine the effkiicy of a{henrJazoIe (ABZ) and ivermectin (IVM)
against gastrointestinal nenialodcs (GIN) in naturally infected goats in the pastoral region of
Karamoja, Uganda. Fifty four
snuiH tCnsl
and from 18 tlocks, were alhicnW.: to
(fenuiie = 36, inale = 18), of 4-6 months
groups(idhendaz<»lv. ivennectin and untreated
control), by a randoinized coinpfeie block design. Each group included 18 goats and treatments
were administered according to weight of each guat, with 5
bw ivermectin. Fecal egg counts (FEC), expressed us
bw albendazole and 0.2Mg/Kg
per yrarn and larval cultures were done
on day zero before treatment and on day 13 posi-treatinent. Anihebniniic efficacy was determined
by the Fecal Egg Count Reduction Test (FECRT). ABZ and IVM reduced FEC by 81.03 and 96.55%,
respectively. The results indicated that nematode resistance was present in the ABZ group.
Coproculture results following albendazole treatment showed that only Hacmonchus spp. survived
treatment. Information from 60 pastoralists indicated that reduced efficacy of the drugs could be
due to prolonged and frequent use of the same anthelmintic and under dosing. Steps should be
taken to limit the spread of resistant nematodes and to restore anthelmintic efficacy.